The 10th Federation of the Asian and Oceanian Physiological Societies Congress

In conjunction with the 75^th Annual Meeting of the Korean Physiological Society

EXCO, Daegu, Korea, 1-4 November 2023

• Takashi Sumikama (Kanazawa Univeristy, Japan)
  

  Molecular Mechanism of Selective Ion Permeation through the K+ Channels: A Computational Study

• Chen Song (Peking University, China)
  

  Molecular dynamics simulations of calcium ion channels with a multisite calcium model

• Katsumasa Irie (Wakayama Medical University, Japan)
  

  Molecular dynamics simulation and structural analysis of the divalent cation blocking mechanism generated in prokaryotic cation channel

• Ben Corry (Australian National University, Australia)
  

  Computer simulations of voltage gated sodium channels: from ion conduction to drug discovery

Ion channels play essential roles in many physiological functions, such as nerve conductions and sensations. Traditionally, electrophysiological measurements have obtained huge insights into the ion conduction and the regulation of channel activity. The underlying mechanisms of these functions should be, in principle, related to molecular motions, and thus observation of such molecular motions is necessary to fully understand the mechanisms. While experimental observation is not yet possible, molecular dynamics (MD) simulations offer a clue: MD simulations use computers to solve the Newtonian equation of motions and visualize the dynamics of ions, channel proteins, lipids, and water molecules at the atomic scale. Recent developments of structural biology have yielded many ion channel structures, which are available for initial configurations for MD simulations. With recent high-performance computers, MD simulations of ion channels can provide not only visualization but also fundamental explanations for physiological functions such as ion conduction and selectivity. Therefore, MD simulations are now becoming a powerful and general tool in physiological studies of ion channels. This symposium will present recent advances in this field that are helpful for understanding (1) ion conduction and selectivity mechanism through the K+ channels, (2) those through the Na+ channels, (3) those through Ca2+ channels, and (4) mechanism of action of drugs such as local anaesthetics and antiepileptics.

• Chris Hedges (University of Auckland, New Zealand)
  

  From insects to mammals to elite athletes: how a comparative physiology approach to help understand how mitochondria adapt to physiological extremes

• Kenya Takahashi (The University of Tokyo, Japan)
  

  A new paradigm for the role of lactate as an important metabolic signal regulating mitochondrial biogenesis

• David Bishop (Victoria University, Australia)
  

  Using ‘omics’ to understand mitochondrial adaptations to different types of exercise

Mitochondria are an extraordinary example of the axiom ‘Form ever follows function’: they are dynamic organelles with crucial roles in many essential physiological functions related to cellular metabolism and homeostasis. Mitochondrial function declines with normal ageing, and compromised mitochondria have been implicated in many chronic diseases. Exercise can stimulate mitochondrial biogenesis, leading to a new normal and many health benefits. A fascinating and important question is what are the molecular mechanisms triggered by different types of muscle contraction that positively affect mitochondrial biogenesis? In this symposium, scientists from New Zealand, Japan, and Australia will present the latest published and unpublished research decoding the critical physiological signals that allow skeletal muscle contraction to create new normal mitochondria. In the first talk, Dr Chris Hedges will use a comparative physiology approach to help understand how mitochondria adapt to physiological extremes – from insects, to birds, to fish, to mammals, to elite endurance athletes. In the second talk, Prof. Hideo Hatta will highlight the latest research from his team and others shaping a new paradigm for the role of lactate in physiology. While originally considered a dead-end metabolite causing fatigue, new research suggests that lactate generated in both physiological (e.g., during exercise) and disease (e.g., cancer) contexts may be an important metabolic signal regulating mitochondrial biogenesis. In the final talk, Prof. David Bishop will present the latest research describing how high-intensity exercise is characterised by the activation of transcriptional pathways associated with mitochondrial stress and the unfolded protein response, combined with structural mitochondrial disturbances, suggesting increased activation of mitochondrial quality control pathways. Results from whole-muscle and single-fibre proteomics performed on human muscle samples will also be presented in support of these findings. In summary, this session will provide an important update on how different physiological stresses help create new normal mitochondria.

• Boyoung Joung (Yonsei University Severance Hospital, Korea)
  

  Extracellular vesicles and arrhythmia; a diagnostic biomarker and treatment

• Junko Kurokawa (Univ Shizuoka, Japan)
  

  Pathophysiological roles of cardiac potassium channel in ventricular repolarization

• Wenjun Xie (Xi’an Jiaotong University, China)
  

  Stretch-induced sarcoplasmic reticulum calcium leak promotes atrial and sinoatrial dysfunction

• Nagomi Kurebayashi (Juntendo Univ, Japan)
  

  Effects of a novel RyR2 selective inhibitor on malignant arrhythmias in CPVT mouse models

• Shi-Qiang Wang (Peking University, China)
  

  Adrenergic mechanisms that partially suppress CPVT constitutively

Intracellular Ca2+ signal, Ca2+ release channels and mechanical signaling are thought to play key roles in the cardiac arrhythmogenesis. This symposium focuses on recent progresses in understanding the cellular and molecular mechanisms for atrial and ventricular arrhythmogenesis. Novel findings on the regulatory mechanisms for altered Ca2+ signalnig and EC coupling in serious cardiac diseases, such as pressure/volume overload and CPVT, based on new technical approaches and mechanical and hormonal signaling, will be presented and discussed in this symposium.

• Sourav Banerjee (National Brain Research Center, India)
  

  LncRNAs at the synapse: Implications in synaptic plasticity and memory

• Dan Ohtan Wang (RIKEN, Japan)
  

  Forebrain-deletion of m6A reader YTHDF3 modulates mouse adaptive behaviors reared in enriched environment

• Timothy Bredy (Univ. of Queensland, Australia)
  

  Synapse-enriched long non-coding RNAs drive synaptic plasticity and memory formation

• Ki-Jun Yoon (KAIST, Korea)
  

  Deciphering the Neural Epitranscriptome: The Roles of mRNA Modification in Neurodevelopment

Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders, from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. This session will discuss the current state of studies on RNA modifications in the brain and provide novel translational perspectives.

• Peihua Jiang (Monnell Chemical Senses Center, USA)
  

  Neuronal Regulation of Adult Taste Stem Cells

• Akiyuki Taruno (Kyoto Prefectural University of Medicine, Japan)
  

  The channel synapse mediates neurotransmission of tastes and beyond

• Hojoon Lee (Northwestern University, USA)
  

  Wiring the Taste System

• Seong Bae Suh (KAIST, Korea)
  

  Postprandial Sodium Sensing in Drosophila

Taste is a specialized chemical sense that detects nutrients and potentially harmful substances within food. It originates on the tongue in the mouth but is further processed in the brain, in conjunction with the postingestive feeling that identifies nutrients in the intestines after food has been swallowed. The ability to detect taste plays a crucial role in shaping our eating habits, holds a direct correlation with our survival, and significantly contributes to the overall quality of our lives.While taste research has historically centered around genes and cellular physiological responses involved in taste detection, recent studies have expanded their focus. They now encompass the development of peripheral taste organs, the formation of synapses and signal transmission mechanisms to the central nervous system, and interactions with sensory perceptions in the intestines. In this session, we discuss the latest advancements in taste research field.

• Somnath Gangopadhyay (University of Calcutta, India)
  

  Prevention of Occupational Health Disorders in Indian informal Sectors : a participatory approach

• Prakash Chandra Dhara (Vidyasagar University, India)
  

  An ergonomic intervention on the manual paddy threshing workstation for reducing occupational health problems of the workers

• Alok Chattopadhyay (Harimohan Ghose College, India)
  

  Workers of garment manufacturing in Kolkata : Increased susceptibility of inflammatory burst, COVID and non- communicàble diseases (NCDs)

• Amit Bandyopadhyay (University of Calcutta, India)
  

  Musculoskeletal Disorders and Occupational Stresses in House Maids of Kolkata, India

Informal work takes place in that part of an economy that is not monitored by any form of government regulation resulting in non-adherence to prevalent labour laws of the concerned country. Workers in the informal sector work incessantly to make a living and consequently develop physical or physiological stress. Labour productivity takes precedence over the health and safety concerns for these workers. Demand for investigation of health and safety issues is a common and genuine demand for workers of informal sector that covers 95 percent of women workers worldwide and is a larger source of employment for women than for men. Women are reporting physiological ailments, physical and mental stress and other health hazards. In 2001, at the International Labour Conference, the challenge for the applications of work comfort in informal sectors was greatly discussed. This topic on informal works is selected to initiate a brainstorming discussion at an international forum to search for strategies, policies and implementations of solutions that could enhance the quality of life of workers in the informal sector. In this symposium, speakers who have made significant contributions from diverse disciplines like occupational health, economics, ergonomics and work and exercise physiology to improve the quality of life and wellbeing of the workers in the informal sector are being nominated to discuss about the sufferings of informal sector workers particularly female workers and to find out ways to alleviate their sufferings. With a view to provide a healthy work environment, it is felt that this conference is an appropriate platform to highlight and discuss physiological, occupational and other health related issues of these workers and to propose appropriate solutions to enhance their life pattern towards a healthy wellbeing.

• Ikuko Takeda (Nagoya University, Japan)
  

  Reactivation of astrocytes reverses pain-like behaviour

• Ryuta Koyama (University of Tokyo, Japan)
  

  Neuronal activity-dependent non-lethal caspase activity guides microglial synaptic phagocytosis and neuronal circuit remodeling

• Eunji Cheong (Yonsei University, Korea)
  

  Glial control of thalamic sensory processing

• Justin Lee (Center or Cognition and Sociality, IBS (Institute for Basic Science), Korea)
  

• Wenbiao Gan (Shenzhen Bay Laboratory, China)
  

  Astrocytic Ca2+ prevents synaptic depotentiation in the motor cortex during motor learning

Higher brain functions, such as learning, memory, and emotion, are expressed by the orchestrated spatiotemporal sequential activities of individual neurons in multiple brain regions. Recently, it has been suggested that glia, traditionally known as the glue in the brain, contribute to the formation of neural circuits by regulating synaptic transmission, the supplement of the nutrition, the number of neurons and synapses during development and maturation. Abnormalities in glial functions may lead to developmental disorders and psychiatric diseases. In this symposium, we will introduce the latest findings of glial physiological function in learning-related synapstic plasticity and for neuronal circuits and brain information. We will also use genetic and imaging approaches to explore the possibility of targeting glia for the treatment of central nervous system (CNS) diseases.

• Rhian Touyz (McGill University Health Centre, Canada)
  

  Oxidative stress as a unifying paradigm in the mosaic of hypertension

• Susan Wray (The University of Liverpool, United Kingdom)
  

  Don't forget pregnant women and children

• Bon Kwon Koo (Seoul National University Hospital, Korea)
  

  Intracoronary hemodynamics for prevention of acute coronary syndrome or sudden cardiac death

• Ingrad Fleming (Goethe University, Faculty of Medicine, Germany)
  

  Metabolic communication between cells in physiology and pathophysiology

• Ashraf Kitmitto (University of Manchester, CV Institute, United Kingdom)
  

  Nanostructural and functional remodelling underpinning the development of diabesity-linked heart failure; a breakdown in cellular quality control processes

Cardiovascular translational and beyond

• Julia Choate (Monash University, Australia)
  

  Supporting student development of research skills in virtual laboratories

• Louise Ainscough (University of Queensland, Australia)
  

  Do-It-Yourself Physiology: Can the Clinical Application of Physiology Be Learnt Online?

• Elizabeth Beckett (University of Adelaide, Australia)
  

  Progressive development of physiology knowledge and research skills using a blended learning approach

• Kay Colthorpe (University of Queensland, Australia)
  

  Beyond the pandemic: How will we use this knowledge to aid student learning?

Laboratory classes are often considered the cornerstone of science education. Such classes allow students to gain greater understanding of theoretical content and gain skills in scientific methods and practices (1),(2). These ‘generic’ skills are often the most critical learning gains in laboratory classes, as they represent the transferable skills students need to succeed in the workplace. However, the onset of the COVID pandemic had a major impact on physiology education, both with regard to students’ engagement with learning content and educators’ delivery of learning materials. In particular, laboratory classes were significantly impacted(3). As the pandemic continued, educators had to develop and evaluate innovative methods to both deliver practical content and to replicate opportunities for students to develop skills normally gained in laboratory classes. Given the critical nature of these skills, a major focus of educational research undertaken during the pandemic was evaluating the skills students learn during laboratory classes and the ways in which various delivery modes could influence students’ skill development (4),(5). This symposium will highlight lessons learned from the pandemic, exploring the type and nature of skills students learn from both an academic and student perspective. Furthermore, it will examine how differing laboratory class design and delivery modes impacted students’ learning gains and discuss how this should influence future curriculum and class design beyond the pandemic.
1. Zimbardi et al (2013) Advances in Physiology Education, 37(4), 303-315.
2. Colthorpe et al (2017) Advances in Physiology Education, 41(1), 154-162.
3. Colthorpe & Ainscough (2021) Advances in Physiology Education, 45(1), 95-102.
4. Zhang et al (2021) Advances in Physiology Education, 45(3), 467-480.
5. Gaganis et al (2021) Advances in Physiology Education, 45(4), 744-748.

• Yosef Purwoko (Universitas Diponegoro, Indonesia)
  

  Physiology Changes in Muscle of Elderly

• Chia-Hua Kuo (University of Taipei, Taiwan)
  

  Exercise, Cellular Senescence, and Human Longevity

• Shizue Masuki (Shinshu University Graduate School of Medicine, Japan)
  

  Synergistic Effects of Exercises + Milk Product Intake in Older People: Background and Evidence

• Fabian C.L. Lim (Nanyang Technological University, Singapore)
  

  The impact of community exercise programmes on metabolic health and muscle functions in older men and women

• Sri Sumartiningsih ((Universitas Negeri Semarang, Indonesia)
  

  Core Strength Training to Improve Strength and Flexibility of Older People

Aging is a challenge for modern life since modern life is related to the bad lifestyle habits. A long and healthy life is what everyone needs to achieve. Certain countries in the world have people with high life expectancies, while many other countries have lower life expectancies. Various ways are done to make the average human age able to reach 100 years or more. Many factors affect a person's age, including daily living habits such as eating healthy and enough food, exercising regularly, enough sleep and rest, also avoiding factors that can cause degenerative diseases or movement disorders.
Cells in the human body are mostly short-lived. Therefore, the senescent cells are widely detectable in embryonic stage and young adulthood. To maintain stable cell population of challenged tissues, a dynamic balance of cell regeneration and cell death is required from repopulating stem cells resided in peripheral tissues during inflammation. However, stem cells develop senescence following a limited cycle of cell division.
Various studies have been conducted to obtain various factors that can improve a person's health, fitness and mental status especially at the time of retirement. Therefore, the discussion of various factors related to efforts to prevent the aging process needs to be elucidated from several aspects. For this reason, this seminar to be held includes several topics related to efforts to prevent aging or to achieve longevity. Especially discussing about the role of nutrition and physical activity on muscle strength, flexibility, cardiovascular capacity, improved mitochondrial function, improving of body cells conditions, suppressed chronic inflammation including using specific nutrient and senolytic supplement to enhance the senescence cellular-lowering effect of exercise and results in an improved endurance performance of aging adults.

• KyeongJin Kang (Korea Brain Research Institute (KBRI), Korea)
  

  Unilateral ephaptic program for sweetness dominance

• Myungin Baek (DGIST, Korea)
  

  Decoding the molecular logic underlying the evolution of vertebrate locomotion

• Kyuhyung Kim (DGIST, Korea)
  

  Maternal aging affects the activities of a sensory neuron via a small RNA pathway

• Chun-liang Pan (National Taiwan University, Taiwan)
  

  Aversive Memory Induced by Mitochondrial Stress: A C. elegans Model

A major goal of neuroscience is to understand how the nervous system senses and integrates environmental cues to drive critically important behaviors. This symposium will present and discuss the circuit mechanisms underlying behaviors in several model animals. Since neuronal and molecular pathways in animals are highly conserved, results from these works are expected to provide insights into related signaling mechanisms in higher organisms.

• Julie Chan (Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan)
  

  Microbial Metabolites and Nutrient-Sensing Signaling in Central Neural Regulation of Blood Pressure

• Je Kyung Seong (Seoul National University and Korea Mouse Phenotyping Center, Korea)
  

  Molecular pathway of exercise-induced health in mouse model

• David Paterson (University of Oxford, United Kingdom)
  

  Transcriptional and Signal Transduction Underlying Neuromodulation of Heart Rhythm in Exercise and Disease

• Ayako Takeuchi (University of Fukui, Japan)
  

  Roles of Mitochondrial Ca2+ Dynamics during Cardiac Workload Transition

• Mario Delmar (New York University, USA)
  

  The athlete's heart and ARVC: When the desmosomal reserve is not good enough

This symposium will be sponsored by The Journal of Physiology and highlight some of most exciting research in cardiovascular and skeletal muscle research, relevant for a better understanding of normal function and responses to changing demands, such as during exercise. A more detailed synopsis of content will be provided, once we have contacted speakers and agreed presentation titles. We request permission of the organizing committee to implement this next step now.

• Ippei Shimizu (Juntendo University, Japan)
  

  Cellular senescence as a therapeutic target for age-related disorders.

• Chang-Myung Oh (GIST, Korea)
  

  Clinical benefits of fenofibrate in obesity-related heart failure and its cardiac mechanisms

• Yong Sook Kim (Chonnam National University Hospital, Korea)
  

  Targeting the Inflammation-driven Cell Phenotypic Changes for Cardiovascular Therapy

• Hun-Jun Park (The Catholic University of Korea, Korea)
  

  Cell therapeutics for myocardial infarction based on iPSC-derived multi-cellular spheroids

• Yoo-Wook Kwon (Seoul National University Hospital, Korea)
  

  KAI1 (CD82) is a key molecule to switch angiogenic milieu to quiescent state

This session is the join session with Korean Society of Cardiology Working Group on Basic Cardiovascular Sciences. As we enter an aging age, the prevalence of various cardiometabolic diseases, such as heart failure and coronary heart disease is increasing. This session will provide the insight of novel mechanism and therapeutic strategy for cardiometabolic disease regarding.

• Jen-Hsuan Wei (Academia Sinica, Taiwan)
  

  γ-TuRC regulates radial migration and neuronal maturation during mammalian cortical development

• Ajioka Itsuki (Tokyo Medical and Dental University, Japan)
  

  Supramolecular Biomaterials for Injured Brain Regeneration

• Shi-Bing Yang (Academia Sinica, Taiwan)
  

  Exploratory Internal State Encoded by Hypothalamic SF-1 Expressing Neurons Drives Social Investigative Behaviors in Mice

• Pei-Chun Chen (National Cheng Kung University, Taiwan)
  

  Activation of KATP channel in brown adipose tissue attenuates depression-like symptoms through dopaminergic neurons in the ventral tegmental area

With the high similarity in physiology and genetics, mice have become the preferred animals for modern biomedical research. Moreover, the recent invention of new tools, including genetic editing, cell-type- specific manipulation, high-resolution in-vivo imaging, and big datasets in biomedicine, has revolutionized our understanding of brain functions under normal and pathological manifestation. This symposium will invite four leading physiologists to share their latest research about using advanced mouse models to investigate the pathophysiological aspects of brain diseases. The topics include imitation behavior/autism, vascular physiology/stroke, energy metabolism/depression, and social behavior/stress. We highly anticipate great idea exchange among the physiologists at this symposium will provide new foundations for both basic and clinical neuroscience, especially in the era of precision medicine

• Seiichi Uchiyama (Tokyo University, Japan)
  

  Research on Thermal Signaling using Intracellular Thermometry

• Cheol-Sang Hwang (POSTECH, Korea)
  

  N-Terminal formyl-methionine acts as a critical determinant for the ribosome-associated protein quality control

• Hyun-Woo Rhee (Seoul National University, Korea)
  

  MitoAtlas: a super-resolution proximity proteome map of mitochondria

• Jun Namkung (Yonsei University Wonju College of Medicine, Korea)
  

  Regulation of brown adipose tissue thermogenesis by mitochondrial calcium uniporter

Mitochondria, as the cellular powerhouse of bioenergetics, involve all biological processes of life, aging, diseases, and death. Mitochondria are essential intracellular organelles to overcome noxious stresses and maintain homeostasis. In this session, top-class mitochondrial researchers present and share their findings on mitochondrial physiology and pathophysiology.

• Ronny Lesmana (Universitas Padjadjaran, Indonesia)
  

  The role of exercise and nutraceuticals in modulating physiological ROS levels

• Kazumi Masuda (Kanazawa University, Japan)
  

  Mitochondrial Protein Import and Its Physiological Significance on Mitochondrial and Cell Function

• Rohit Sinha (SGPGIMS, India)
  

  Metabolic Regulation and nutraceutical

• Ronald Hamidie (Universitas Pendidikan Indonesia, Indonesia)
  

  Physiologic aspect of Nutraceutical agents as Cell Energetic, Mitochondria for exercise performance

Nutraceuticals agents may be used to improve health, delay the aging process, prevent chronic diseases, increase life expectancy, or support the structure or function of the body. The food products used as nutraceuticals can be categorized as dietary fibre, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants, and other different types of herbal/ natural foods for supporting treatment like obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, cholesterol etc. In whole, ‘nutraceutical’ has led to the new era of medicine and health, in which the food industry has become a research oriented sector. Unfortunately, by the global market is flooded with nutraceuticals and cosmeceuticals claiming to be of natural origin and sold with a therapeutic claim by major online retail stores. Apart from the traditional formulations, many manufacturers and researchers use novel formulation technologies in nutraceutical and cosmeceutical formulations for different reasons and objectives. Manufacturers tend to differentiate their products with novel formulations to increase market appeal and sales. On the other hand, researchers use novel strategies to enhance nutraceuticals and cosmeceuticals activity and safety. Thus, physiological assessment and health facts proven are very important to be understood. To understand deepness of nutraceutical’s physiological impacts, we design a session with subtopic as followed : Nutraceutical as ROS regulator, Friends or Foe; Inflammation/Immune system and nutraceuticals; Metabolic Regulation and nutraceutical; Physiologic aspect of Nutraceutical agents as Cell Energetic, Mitochondria for exercise performance. The objective of sessions is to assess the current understanding in nutraceuticals and cosmeceuticals. Our session will provide an overview of physiological perspective of nutraceuticals and cosmeceuticals current technologies, highlighting their pros, cons, misconceptions, regulatory defin

• Tae Woo Kim (Korea University, Korea)
  

  Immunotherpay Drives Metabolic Reprogramming of Therapy-refractory Tumor cells

• Mi-Na Kweon (University of Ulsan College of Medicine, Korea)
  

  Targeting the gut microbiota on cellular heterogeneity in cancer

• Jihyun F. Kim (Yonsei University, Korea)
  

  Microbiota and gastrointestinal cancer: pathology, prognosis, and treatment

• Yanan Yang (Anhui Medical University, China)
  

  Identification of Novel Biomarkers and Combinational Targets for Immune Checkpoint Therapies of Lung Cancer

During tumorigenesis, cancer cells promote the recruitment of stromal cells including endothelial cells, cancer-associated fibroblasts, stellate cells, adipocytes, and immune cells from neighboring tissue, establishing a dynamic tumor microenvironment to modulate the cancer progression. Moreover, recent studies suggest that the microbiome and its metabolic products also play a key role in almost every step of cancer initiation, progression, and metastasis. The tumor microenvironment coordinates proliferation, angiogenesis, and metastasis via the secretion of a variety of growth factors, cytokines, and bile acids, reprogramming cellular metabolism. In this session, four distinguished speakers will present their latest discoveries on how stromal cells and cancer cells communicate with each other. This session may allow us to find the vulnerability of these interactions, which can be harnessed to treat cancers.

• Yun Wang (Peking University, China)
  

  Collaborative approach of basic-clinical teachers in teaching during different organ-system based curriculum models

• Imelda Rosalyn Sianipar (Universitas Indonesia, Indonesia)
  

  Integration of basic-clinical physiology using vignette questions for assessment of Indonesian student

• Samina Malik (University College of Medicine and Dentistry, Lahore, Pakistan)
  

  The practice of Exposure to Simulated and Real patients along with Doctor patient role play in CBL and PBL tools for horizontal and vertical integration at the University College of Medicine and Dentistry (UCMD), The University of Lahore (UOL), Lahore, Pakistan

• Ke-Li Tsai (Kaohsiung Medical University, Kaohsiung, Taiwan)
  

  Enhancing Basic-Clinical Medical Sciences Integration while Retaining the Core Principle of Physiology in Organ-System Based Curriculum

• Jae Boum Youm (Inje University, Korea)
  

  Collaborative approach of basic and clinical medicine in teaching of clinical presentation and pathophysiology

Organ-system based curriculum is adopted by many medical colleges worldwide. It integrates multiple subjects, including the anatomy, histology, physiology, pathology, pharmacology, and clinical courses. Students learn to form the integrative thinking from the macroscopic to the microscopic perspective, from the morphology to the function, and from the normal condition to the disease state. However, there remains some open questions for the application of organ-system based curriculum. What are the teaching objectives of this integrated curriculum? How to organize the teaching contents? What kinds of teaching methods can be used to achieve those goals? How to attain the satisfactory integration but not simple combination? How to evaluate the outcome of the integration? What are the limits or disadvantages of organ-system based curriculum compared to the traditional subject-based curriculum? Most important is how to improve the collaboration of basic-clinical teachers in teaching. The exploration of these questions is helpful for promoting the better application of the organ-system based curriculum in the medical colleges.

• Changtao Jiang (Peking University, China)
  

  Unlocking the Potential of Gut Microbial Enzymes for Precision Treatment of Metabolic Diseases

• Peter Bai (University of Debrecen, Hungary)
  

  Tumor – microbiome interactions in breast carcinoma

• Eun-Kyeong Jo (Chungnam National University, Korea)
  

  Microbiota-mediated immune modulation in mycobacterial infection

• Linda Chia-Hui Yu (National Taiwan University College of Medicine, Taiwan)
  

  Microbiota dysbiosis and gut barrier dysfunction: cause or consequence?

The human body harbors up to 1014 microbes with over 1000 species of microorganisms found in cohort studies. These bacteria, vira, archaea, and fungi populated the gastrointestinal tract, respiratory tract, mammary glands, and skin. The composition and metabolites of microbiota played essential roles in maintaining a mutually beneficial relationship termed symbiosis for human health. Nevertheless, microbiota dysbiosis may predispose to disease development. Gut microbiome is constituted of mostly four bacterial phyla, Bacteroides, Firmicutes, Actinobacteria, and Proteobacteria. Another core component is the gut virome composed of Caudovirales order and Microviridae family. The gut microbes are normally confined in the lumen and are not in direct contact with epithelium which is a crucial barrier with subcellular structures of tight junctions and brush borders to maintain a symbiotic relationship. While the host provides space and nutrients for microbial growth, eubiotic microbiota are involved in pathogen competition, epithelial turnover and barrier fortification, metabolic functions, and shaping of the mucosal immunity. Microbiota dysbiosis are associated with the pathogenesis of many human diseases, including colorectal cancers, breast cancers, inflammatory bowel diseases, type 2 diabetes, metabolic disorders, and neurodegenerative diseases. Accumulating evidence implicated the emergence of pathobionts (opportunistic pathogens converted by commensals) and their imbalance with eubiotics played critical roles in disrupting the gut barrier and promoting polygenic disease development. In the post-human genome era, much attention is now focused on this complicated yet neglected ecosystem. The co-evolution of host and microbes is now considered a critical aspect for maintenance of human health, which is a new era that awaits to be explored in the modern discipline of physiome.

• Irfanuddin Irfanuddin (Sriwijaya University, Indonesia)
  

  Role of Lifestyle in Neurogenesis and Neuroplasticity

• Titis Nurmasitoh (Universitas Islam Indonesia, Indonesia)
  

  Moderate-Intensity Intermittent Exercise Induces Neuroplasticity in Rat Model of Hippocampal Degeneration

• Nia Kurnianingsih (Brawijaya University, Indonesia)
  

  Anthocyanin Modulation on Behaviors and Brain Parameters in Stress-Induced Animal Model

• Khairun Nisa Berawi (University of Lampung, Indonesia)
  

  Probiotics as Neuroplasticity Agent to Neurodevelopment and Cognitive Function in Stunting

• Nurhadi Ibrahim (Universitas Indonesia, Indonesia)
  

  Translational Regulation of Centella asiatica-Induced Synaptic Plasticity in Neurodegenerative diseases Predicted by Network Interaction

Neurodegenerative diseases are pathologies characterized by the irreversible destruction of certain neurons and progressive and incapacitating loss of certain functions of the nervous system and are the main causes of dementia. Neurodegenerative diseases are caused by genetic and environmental interactions. Several biological processes play important roles in the development of neurodegeneration. This is an extraordinarily significant factor influencing neuropathology, especially progressive neurodegeneration. However, the cellular and molecular mechanisms underlying this pathological procedure have not been fully elucidated. This meeting will describe the mechanisms related to
neuroplasticity and neurodegeneration and in the degenerative processes and cell death and discuss the effectiveness of several strategies that may create neuroprotection, neurorehabilitation, and increase the quality of life.

• Eun Hui Lee (Catholic University of Korea, Korea)
  

  The roles of STIM proteins in the cytosolic Ca2+ levels of skeletal muscle cells

• Takashi Murayama (Juntendo University, Japan)
  

  Reconstitution of skeletal muscle excitation-contraction coupling: toward understanding of its molecular mechanism and related diseases.

• Toshiko Yamazawa (Jikei University, Japan)
  

  Characterization of type 1 ryanodine receptor knock-in mice with malignant hyperthermia-associated mutations

• Zhiguang Yuchi (Tianjin University, China)
  

  Structural basis for diamide modulation of ryanodine receptor

In skeletal muscle, the depolarization of t-tubule membrane triggers Ca2+ release from the sarcoplasmic reticulum (SR) to cytoplasm via ryanodine receptor type 1 (RyR1) on the SR membrane, which results in the subsequently muscle contraction (known as excitation-contraction coupling (ECC)). ECC of skeletal muscle has attracted a great attention and, in addition, recent advances in structural analysis using cryo-EM and rapid genome-wide screens have led us to many novel findings in the physiological and pathophysiological properties of ECC in skeletal muscle. Here, in this proposed symposium, we would like to address recent advances in ECC under multilateral approaches. Dr. Murayama and his colleagues (Japan) have proposed molecular mechanisms of disease-causing mutations in the components of ECC and possible therapeutic approaches using a reconstituted ECC machinery (1). Dr. Lee and her colleagues (Korea) have been investigating intra- and extra-cellular Ca2+ movements in skeletal muscle and pathological mechanisms in muscular dystrophies in terms of Ca2+ movements (2). Malfunctions of RyR1 by mutations cause various skeletal muscle diseases including malignant hyperthermia and various types of myopathies. Dr. Yamazawa and her colleagues (Japan) have been investigating the RyR1 inhibitors using transgenic mice with RyR1 mutations, which would be useful to control the skeletal muscle functions in disease states (3). Dr. Yuchi and his colleagues (China) have investigated the structure of RyR and its modulations by insecticides, which would give us rationale design of novel insecticides (4). We are very sure that this symposium will fulfill the interests of FAOPS members who are investigating physiological and pathophysiological properties of muscles, including cardiac, skeletal or smooth muscle.
1. Murayama T. et al., J Gen Physiol, in revision.
2. Woo J.S. et al., Exp Mol Med, 52:1908-252020.
3. Yamazawa T. et al., Nat Commun 12:4293, 2021.
4. Ma R. et al., Nat C

• Maofu Liao (Southern University of Science and Technology, China)
  

  Cryo-EM driven paradigm shift of ABC transporter mechanism

• Hyungho Lee (Seoul National University, Korea)
  

  Elucidating the Molecular architecture of the Gαi-bound TRPC5 ion channel

• Young Cheul Shin (Southern University of Science and Technology, China)
  

  Structural Basis of Voltage-Gated Calcium Channels

• Hyun-Ho Lim (Korea Brain Research Institute (KBRI), Korea)
  

  Cryo-EM structure of a calcium-activate chloride channel BEST1 in a wide-open state

• Jae-Sung Woo (Korea University, Korea)
  

  Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM

After the ‘resolution revolution’ of the cryo-electron microscopy (cryo-EM), structures of many ion channels have been revealed owing to the astonishing development in the method. In this symposium, we look forward to discover how the single particle cryo-EM enabled us to understand atomic structure of ion channels, in a historic context. Moreover, we will explore how ion selectivity can be manifested in a structural manner, namely, how the structure dissects cations from anions, and vice versa. Last but not least, we look into structure-function relationship of gap junction proteins, an essential component of cell-to-cell communication. Through this symposium, we expect to learn pathophysiological characteristics of ion channels in a submolecular level.

• Jaewon Ko (DGIST, Korea)
  

  Modulation of neural circuit properties by synaptic suppressors

• Jong-Woo Sohn (KAIST, Korea)
  

  Neural circuit of orexin-induced hyperphagia

• Lukas Ian Schmidt (RIKEN, Japan)
  

  Thalamocortical Network Dynamics Underlying Perceptual Inference

• Jong Cheol Rah (Korea Brain Research Institute (KBRI), Korea)
  

  Opposite-directional Activity of posterior parietal cortex neurons in erroneous decision-making during delayed match-to-sample task

A brain is operated by millions of parallel, intertwined, and overlapping neural circuits. Neural circuits are built by synaptic connections that not only transfer information from one neuron to the next, but compute it as it is being transferred. The specificity of synaptic connections between neurons and of the diverse properties of these connections define the anatomical and physiological architecture of neural circuits, but how this specificity is achieved is only now beginning to emerge. This symposium will invite four neuroscientists to discuss the recent findings that are relevant to address trending and major questions that are critical for understanding how the structure and function of neural circuits are determined.

• Enoch Perimal (University of Adelaide, Australia)
  

  Innovative approaches in physiology teaching – the supporting role of technology

• Mei-Ling Tsai (National Cheng Kung University, Taiwan)
  

  Application of AI Technology on Lab Teaching in Physiology

• Fumihito Ono (Osaka Medical and Pharmaceutical University, Japan)
  

  Modules of physiology laboratory using zebrafish

• Sarmishtha Ghosh (Bhaikaka University, India)
  

  Ensuring cognitive presence in class - judicious use of technology

• Mangala Gunatilake (University of Colombo, Sri Lanka)
  

  Integrated Systems Physiology - Sri Lankan Experience

• Dong Hyeon Lee (CHA University, Korea)
  

  Optimal blended subject design (non-face-to-face real-time class, recorded video, and face-to-face assessment combination model) and effect analysis on mastery learning

Technology enabled teaching learning activities have gained grounds in the current era of formal and informal education. Teaching of Physiology in medical schools as well as in other health sciences courses have moved a long way from the conventional lecture and tutorial based methods to newer strategies supported by different technology enabled tools which ensure efficient and effecting learning in the current generation of students. Issue of online teaching has also been very challenging during the redcent past and is continuing still now as students have become familiarized with the online self paced learning strateges. This symposium has gathered speakers from different parts of the globe to discuss various ways and means to use technology to deliver topics of Physiology enhancing conceptual learning in the students.

• Tohru Minamino (Juntendo University, Japan)
  

  Targeting senescent cells for the treatment of age-associated disease

• Myung-Shik Lee (Soonchunhyang Institute of Medi-bio Science, Korea)
  

  TFEB activation as a response to lysosomal stress in obesity or metabolic syndrome - Role of TFEB activation as a potential measure against senescence –

• Yong-ho Lee (Yonsei University, Korea)
  

  Progression of cellular senescence and immunosenescence in non-alcoholic steatohepatitis

• So-Young Park (Yeungnam University, Korea)
  

  Adipose tissue senescence in insulin resistance

Cellular senescence is the cessation of cell proliferation caused by various factors, including metabolic stresses. Senescent-associated secretory phenotype (SASP), which is released by senescent cells, causes nearby normal cells to become senescent cells. The accumulation of senescent cells impairs tissue repair and function, eventually leading to tissue aging and aging-related chronic illnesses such as type 2 diabetes and non-alcoholic steatohepatitis. As a result, eliminating senescent cells (senolytics) or reverting senescent cells to young cells (senomorphics) can help to delay or treat aging and aging-related disorders. This symposium discusses senescent cells as a target for the treatment of metabolic disease.

• Seok-Hyung Kim (Sungkyunkwan University, Korea)
  

  PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression

• Minsuk Kim (Ewha Womans University, Korea)
  

  Crustacean ECM derived miRNAs induce tumor cell death

• Pilnam Kim (KAIST, Korea)
  

  Deconstruction of colorectal cancer microenvironment

• Honami Naora (The University of Texas, MD Anderson Cancer Center, USA)
  

  Cell dynamics in the omentum: Insights into metastasis prevention

The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells and extracellular matrix (ECM) components is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to increase the multidrug resistance ending in cancer cell progression and metastasis. This symposium presents the diverse aspects of tumour microenvironment research, and we hope it will be a valuable resource to research scientists, clinicians and students interested in this field.

• Julia Shanks (The University of Auckland, New Zealand)
  

  The cardiac vagus has a vital role in maintaining coronary artery blood flow during exercise

• Krekwit Shinlapawittayatorn (Chiang Ming University, Thailand)
  

  Vagus Nerve Stimulation and Its Cardioprotective Effects Against Myocardial Ischemia/Reperfusion Injury

• Lindsea Booth (University of Melbourne, Australia)
  

  Selective Optogenetic Stimulation of Efferent Fibres in the Vagus Nerve of a Large Mammal

• Jae-Jun Song (Korea University Medical School, Korea)
  

  Clinical application and vagus nerve stimulation

Ischemic heart conditions are one of the top categories in the world health system accounting for 30% mortality rate worldwide. Common therapeutic approaches including medications or device therapy have been widely used by cardiologists with fairly good outcomes. However, these approaches could not induce remascularization in the ischemic heart region inorder to prevent progression to heart failure. The 21st century has been beginning of a very promising era in the field of medicine as novel therapeutic approaches have been introduced, researched and found its way to the clinics particularly for diseases with no effective treatment. Cell therapy is one of these novel therapeutic approaches that attracted high attention and has been widely experimented for diseases with no efficient cure including ischemic heart conditions. Different modalities of cell therapy have been employed for ischemic heart diseases including multiple cell types, various dosing and delivery systems. Although promising, the results of clinical trials seems to be confounded by inter-trial and inter-patient variability making an accurate conclusion challenging. And exactly for this reason, the recommendation of any cell type or dosing has been missing so far. Furthermore, although the results of mesenchymal stem cell therapy were promising for ischemic heart conditions, but still not relevant enough to be translated and be routinely used in clinics. In parallel to investigate cell therapy, interest in cell products’ therapy of myocardial infarction (MI) has followed due to the potential of such modalities for clinical translation, high replicability and off-the-shelf accessibility. In this symposium, we will discuss in vitro and preclinical studies which were performed by the invited speakers in line with global efforts in this regard. The vagus nerve innervates most organs and has the potential to influence organ function in numerous ways. This symposium will take a broad integrative approach to the study of the vagal nerves to better understand its role both during normal physiology and consequently to use this as a treatment target during pathology.
We will start off with Dr. Julia Shanks from New Zealand will then speak on her data using direct recordings from the cardiac vagal nerve and how activity in this nerve modulates heart function during during exercise. We will then move to pathophysiology where A/Prof. Krekwit Shinlapawittayatorn from Thailand who will speak about t

• Alex Binshtok (Hebrew University, Israel)
  

  Nociceptive Free Nerve Endings - The Heralds of Pain: Biophysical and Structural Plasticity of Nociceptive Free Nerve Endings Underlying Pathological Pain

• Chien-Chang Chen (Academia Sinica, Taiwan)
  

  Differential roles of anterior paraventricular nucleus in regulating mechanical hypersensitivity and aversion behavior in formalin pain model

• Yukari Takahashi (Jikei University School of Medicine, Japan)
  

  Functional and anatomical analysis of the connections between neurons activated in the process of pain chronification

• Choong-Wan Woo (Sungkyunkwan University, Korea)
  

  Personalized functional brain models of chronic pain

• Guo-Gang Xing (Peking University, China)
  

  A Neural Circuit for Comorbid Anxiety Symptoms in Bone Cancer Pain

Despite the remarkable advance in the knowledge of the molecular mechanisms of nociception since the identification of TRPV1 channels, the physiological mechanisms underlying chronic pain, from which more than 20% of the population suffer, remain unsatisfactorily explored, making it a serious global health issue, including the Asian-Oceanian regions. This symposium, composed of 3 male + 2 female young but expert researchers from 5 different FAOPS countries/regions, will present state-of-the-art findings from various standpoints from the free nerve ending plasticity to the nociplastic maladaptation in the hypothalamic-limbic-brainstem networks as well as functional brain imaging in human patients. The two organizers and three speakers are the core members of the “Asian Pain Symposium,” held every 2 years as an international symposium in various Asian countries/regions. Also, one of the organizers and three speakers are regular members of the “International Pain Mechanism Conference” held every 2 years in European countries. The subjects dealt with by the 5 speakers cover broad aspects of the most updated concepts of the physiological mechanisms underlying chronic pain establishment, including “Biophysical and structural plasticity of nociceptive free nerve endings underlying pathological pain” (Binshtol), “Differential roles of paraventricular nucleus in regulating mechanical hypersensitivity and aversion behavior in formalin pain model” (Chen), “Nociplastic pain-associated parabrachial-amygdala neurons and their active role in widespread sensitization” (Takahashi), “Chronic pain and pain-related anxiety and depression” (Xing) and “Personalized functional brain models of chronic pain” (Woo). This symposium is one of the two official proposals from the Physiological Society of Japan. The proposer, Fusao Kato, used to be the vice-president for academic affairs (2012-2018) of the PSJ. He was also the vice-president and treasurer of the FAOPS2019 Congress, Kobe, Japan, indicating that he has been deeply involved in FAOPS activities in his career. All speakers agreed to participate in this symposium if accepted.

• Xianshu Bai (University of Saarland, Germany)
  

  Oligodendrocyte precursor cells shape inhibition in medial prefrontal cortex

• Ko Matsui (Tohoku University, Japan)
  

  Metaplasticity augmentation by acid glia in cerebellar motor learning

• Zhihua Gao (Zhejiang University, China)
  

  Microglia modulate general anesthesia through P2Y12 receptor signaling

• Hauke Werner (Max Planck Institute for Multidisciplinary Sciences, Germany)
  

  Quantitative proteome analysis to discover myelin proteins relevant for a healthy nervous system

Glial cells are crucial players of brain function in health and disease. In particular, they modulate neural circuit activity by modifying synaptic activities and myelin formation to spatiotemporally regulate the neural circuits. In addition, aberrant glial function can cause the initiation and the progression of many neurodegenerative diseases. In this symposium, Xianshu Bai (PI and group leader, University of Saarland, Germany) will present how interneuron and NG2 glia communication during development determines neural circuit and behavior. The presentation of Ko Matsui (Professor at Tohoku University, Japan) will highlight a novel proton-dependent release mechanism of glutamate from astroglia for synapse plasticity in learning and memory. Zhihua Gao (Professor at Zhejiang University, China) will address the dual function of microglial hexokinase 2 for brain function in health and ischemic stroke. Hauke Werner (Team leader at Max-Planck-Institute of multidisciplinary science, Germany) will present their recent findings of oligodendrocyte/myelin in the evolutionary point of view and further address the molecular mechanisms how oligodendrocytes are involved in progressive axonopathy. Four speakers, with diversities in original regions and genders, have been selected based on their recent and exciting achievements demonstrating glial cells as indispensable element for brain function in health and disease. This symposium will provide a novel and comprehensive view how glial cells shape neural circuit and brain function.

• Hiromi Imamura (Kyoto University, Japan)
  

  Visualization and detection of the cellular energy currency with genetically encoded fluorescent biosensors

• Seung-Kuy Cha (Yonsei University Wonju College of Medicine, Korea)
  

  Anti-aging gene Klotho in calcium signaling

• Hyoung Kyu Kim (Inje University, Korea)
  

  Cereblon, a novel cardiac contractile regulator

• Kazuhiro Nishiyama (Kyushu University, Japan)
  

  Redox-dependent alternative internalization (REDAI) of purinergic P2Y6 receptor regulates colitis but not non-alcoholic steatohepatitis

• Sang-Min Park (Chungnam National University, Korea)
  

  System analysis for alleviating muscle atrophy using medicinal herbs

In this symposium, we share the physiological and pathological correlations of the signal transduction mechanisms regulating 'energy metabolism and stress', which are the core of life phenomena and disease development, and the latest research trends in disease treatment targets. In addition, we would like to look at the possibility of future clinical application.

• Martin Morad (University of South Carolina, USA)
  

  Mutations in RyR2 calcium binding residues of hiPSC-CMs disable CICR, but do not suppress spontaneous beating, revealing cardiac EC-coupling remodeling

• David Eisner (University of Manchester, United Kingdom)
  

  How does calcium leak into cardiac myocytes? Consequences for arrhythmias.

• Jin Han (Inje University College of Medicine, Korea)
  

  Exercise-induced cardiac remodeling

• Sun-Hee Woo (Chungnam National University, Korea)
  

  Distinct alterations in local calcium signaling in right and left atrial myocytes in a rat model of pressure overload

• Yin Hua Zhang (Seoul National University College of Medicine, Korea)
  

  Splicing variants of neuronal nitric oxide synthase in the heart - Ca regulation and beyond

Global and local Ca2+ changes in cardiac myocytes regulate cardiac contractility and membrane excitability. Alterations in the Ca2+ signaling under pathological conditions are major mechanisms for ventricular and atrial myocyte dysfunction, muscle remodeling and arrhythmogeneisis. Alterations of atrial and ventricular Ca2+ signals and their alternans, caused by genetic and mechanical stimuli will be extensively discussed in this session. In addition, role of mutations of ryanodine receptors that are the major Ca2+ release channels, in human cardiac arrhythmia. Furthermore, novel mitochondrial regulatory mechanisms under exercise and hypertension-associated NO signaling changes for the regulation of cardiac muscle function will be presented. This will give a novel insight on the strategy to treat life-threatening cardiac diseases, such as heart failure, arrhythmia, and hypertension.

• Hiroko Kishi (Yamaguchi University Graduate School of Medicine, Japan)
  

  The role of calpain protease and vimentin cleavage in the signal transduction of abnormal vascular smooth muscle contraction

• Jee In Kim (Keimyung University School of Medicin, Korea)
  

  A role for HDAC1/c-Myc axis in obese hypertension

• Katsuya Hirano (Kagawa University School of Medicine, Japan)
  

  Unique responsiveness of pulmonary artery smooth muscle to thrombin as a promising target for treatment of pulmonary hypertension

• Sun Sik Bae (Pusan National University School of Medicine, Korea)
  

  Phenotypic Modulation of Vascular Smooth Muscle Cells

• Yoshito Yamashiro (National Cerebral and Cardiovascular Center Research Institute, Japan)
  

  Matrix-mediated mechanotransduction underlies vessel wall remodeling

This proposed session is to discuss pathophysiological significances of new signaling pathways linked to vascular diseases with experts in the field. Vascular smooth muscle cell is capable of highly adapting to environmental changes by adjusting the robustness of their proliferation and contraction. Abnormal regulation in smooth muscle cells has been linked to the pathologic remodeling and contraction of vasculatures. To fully understand vascular pathophysiology, we must keep exposing elements responsible for dysfunctions of vascular smooth muscle cells. In this session, five experts will discuss their recent discoveries in the vascular pathophysiology field. Dr Kishi is a leading investigator in the vasospasm research, and she will discuss the mechanism of how the vasospasm initiator triggers hyperphosphorylation of myosin and hypercontraction of smooth muscle. Dr Kim is a trailblazer studying pathophysiological gene regulation in vascular smooth muscle, and she will discuss the mechanism regulating angiotensin II signaling under hypertensive conditions. Dr Hirano is an established leader in vascular pathophysiology, and he will discuss new therapeutic targets of pulmonary hypertension based on his recent finding on PAR1 signaling. Dr Bae is a key contributor to understanding vascular inflammation, and he will discuss newly discovered signaling pathways that regulate the phenotypic switch of vascular smooth muscle cells. Dr Yamashiro is a pioneer of the mechanotransduction research in arteries, and he will discuss the mechanisms of how disturbances in Hippo signaling trigger the remodeling of vascular walls. Lines of knowledge and techniques that will be discussed by this group of speakers are expected to inspire the audience beyond the vascular physiology research field.

• Won-Suk Chung (KAIST, Korea)
  

  Stress evokes mental disorder like behaviors via astrocytic MERTK-dependent synapse phagocytosis

• Jun Nagai (Riken Center for Brain Science, Japan)
  

  Probing behaviorally consequential astrocyte ensembles

• Shun-Fen Tzeng (National Cheng Kung University, Taiwan)
  

  The experience of stress resulting from dietary factors or social interactions elicits glial reactivity in specific brain regions and the development of mood disorder

• Shuo-Chien Ling (National University of Singapore, Singapore)
  

  Deciphering TDP-43 functions in glia

• Yi-Hsuan Lee (National Yang Ming Chiao Tung University, Taiwan)
  

  Astrocytes in Chronic Disease-Associated Mental Disorders

Brain health affects the quality of life and is deeply impacted by the environmental changes and epidemic. Recent advances are increasing our awareness on the important role of Glial cells, which are activated by various forms of intrinsic and extrinsic challenges, in regulating neuronal activities and circuit homeostasis for adaptation. In this symposium, we aim to present the cutting-edge studies on the multi-tasking astrocytes, brain resident immune cell microglia, and myelin-forming oligodendrocytes in neurophysiology and brain disorders. Glia scientists from Korea, Japan, Singapore, and Taiwan will join force to deliver their most recent discovery to the conference participants. The proposed topics include astrocyte physiology includes synaptic elimination (Chung WS, Korea), neuronal excitability (Lee YH, Taiwan), and behavioral consequence (Nagai J, Japan). Microglial physiology in stressed brain (Tzeng SF, Taiwan) and molecular mechanism of myelination in oligodendrocytes (Ling SC, Singapore) will be presented.

• Tetsuro Watabe (Tokyo Medical and Dental University, Japan)
  

  Targeting tumor microenvironment networks for developing novel therapeutic strategies

• Byung-Hyun Park (Jeonbuk National University Medical School, Korea)
  

  p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: Role of Nrf2 phosphorylation

• Jae Ho Cheong (Yonsei University, College of Medicine, Korea)
  

  Vascularized tumor organoid platform for implementing precision oncology for gastric cancer

• Kyungmoo Yea (DGIST, Korea)
  

  Reprogramming of T cell exosmes using surface engineering of IL2 induces potent anti-cancer effects

Tissue microenvironment including blood vessels is emerging to play an important role in disease pathogenesis. For example, it is known that vascular inflammation or abnormalities lead to the pathological progression of organs, so disease progression and treatment are presented and discussed from this point of view.

• Yasushi Okamura (Osaka University, Japan)
  

  Voltage-sensing phosphoinositide phosphatase; mechanisms and functions

• Byung Chang Suh (DGIST, Korea)
  

  PI(4,5)P2 activation of proton-activated chloride (PAC) channels

• Byoung-Cheol Lee (Korea Brain Research Institute (KBRI), Korea)
  

  Lipid scrambling by TMEM16 scramblases

• Jinsoo Seo (DGIST, Korea)
  

  Co-imaging lipids and proteins on the plasma membrane by TOF-SIMS reveals increased localization of amyloid precursor protein on lipid rafts in AD neurons

Membrane lipids play important roles in signaling reactions. They mark the identity of specific subcellular membrane compartments, serve as membrane recognition sites for specific cytoplasmic proteins, and act as membrane-delimited second messengers modulating the activities of some membrane proteins including ion channels. They are involved in cellular signaling cascades in a wide variety of tissue and cell types. The purpose of this session is to highlight recent developments in the regulation of membrane lipids and their functional role in physiology and pathophysiology.

• Ali Jahanshahi (Maastricht University Medical Center, Netherlands)
  

  Injectable nanoelectrodes enable wireless deep brain stimulation in mice

• Zahra Ghasemi (Lunenfeld-Tanenbaum Research Institute, Canada)
  

  The role of metabotropic glutamate receptor in antiepileptiform activity of low-frequency stimulation in rat hippocampal acute slices

• Amir Shojaei (Tarbiat Modares University, Iran)
  

  Ventral tegmental area participates in social memory formation

• Javad Mirnajafi-Zadeh (Tarbiat Modares University, Iran)
  

  Involvement of dopamine receptors in therapeutic effects of deep brain stimulation

Deep brain stimulation (DBS) is a therapeutic manner for several brain disorders. Although this method has been used for a long time, its mechanism of action, best pattern of stimulation and suitable brain targets are not completely determined. In this symposium we will present original data from our recent studies that aim to address these issues. Considering the probable role of neuromodulators in DBS action, in a set of experiments we tried to find some documents to show the role of dopamine in DBS actions. The activity of D1-like and D2-like dopaminergic receptors depend on the neural firing rate of brain dopaminergic nuclei such as ventral tegmental area (VTA). The activity of VTA dopaminergic neurons may be managed through applying DBS in VTA. In this symposium we will talk about the therapeutic effects of low-frequency DBS of VTA on seizure and high-frequency DBS of VTA in treatment of Alzheimer’s disease. In addition, the effect of both high- and low-frequency DBS of VTA on social memory will be explained. Parallel to dopamine receptors, the role of metabotropic glutamate receptors in mediating the inhibitory effect of low-frequency DBS on epileptiform activities will be also discussed in the symposium. Next, we will demonstrate our recent research on an alternative approach, which involves using Magnetoelectric Nanoparticles (MENPs) that wirelessly transmit electrical signals to the brain in response to an external magnetic field. Importantly, this mechanism of modulation requires no genetic modification of neural tissue and allows animals to freely move during stimulation. Using these nanoelectrodes, we show neuronal modulation in vitro and in deep brain targets in vivo. We also show that local thalamic modulation promotes modulation in other regions connected via basal ganglia circuitry, leading to behavioral changes in mice.

• Kea Joo Lee (Korea Brain Research Institute, Korea)
  

  Altered synaptic architecture in the human dysplastic neocortex

• Jinseop Kim (Sungkyunkwan University, Korea)
  

  Climbing fiber to interneuron synapse supports cerebellar motor learning

• Jaerin Sohn (Osaka University, Japan)
  

  Presynaptic regulation of dendritic segment-selective synaptic plasticity in motor learning

• Yoshiyuki Kubota (National Institute for Physiological Sciences, Japan)
  

  A large volume EM data set and microcircuit analysis of neocortex

We have made significant improvement in serial electron microscopy (EM) technique in this decade. New EM technologies, combined with cutting edge light microscopy, gives new insights into neural microcircuit structure and dynamics. In this symposium, we would like to introduce the new EM technologies including high throughput and large volume EM imaging, image analysis of serial electron micrographs, and AI-assisted deep learning automated segmentation for large volume EM data sets. We describe a few examples regarding functional spine dynamics using combined two-photon microscopy, serial EM reconstruction which observed the mouse primary motor cortex during a motor learning task, and block-face EM reconstruction that revealed a new circuit that may help the synaptic plasticity in the cerebellum. We hope the symposium will give you some idea how to analyze brain structure and function in neuroscience research with the cutting edge EM technologies.

• Hyun Jin Kim (Sungkyunkwan University, Korea)
  

  Autophagy regulation by the intracellular Ca2+ channel TRPML3

• Bo Hyun Lee (Gyeongsang National University, Korea)
  

  Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A

• Tae-Sik Sung (Seoul National University Cancer Hospital, Korea)
  

  Protease-activated receptors regulate excitability of SIP syncytium through different ion channels

• Min Seok Song (Gyeongsang National University, Korea)
  

  Regulation of CFTR Trafficking via Cell Stress-Associated ER Structural Changes

This symposium is designed to provide an overview of the latest studies of ion channel; focusing on the importance of ion channel function under both physiological and pathological conditions.

• Peyman Golshani (UCLA, USA)
  

  Correlates of social behavior in cerebellum and anterior cingulate cortex.

• Keiko Tanaka-Yamamoto (KIST, Korea)
  

  Cerebellum as a crucial component in the regulation of depression-like behaviors

• Yu Kyeong Kim (Seoul National University, Korea)
  

  Neurobiological imaging of neuropathic pain using PET

• Sang Jeong Kim (Seoul National University, Korea)
  

  Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory

The cerebellum compares motor command information with sensory information following movement to calculate motor errors and sends the results to the cerebrum to contribute to error-free motor performance. Here, we would like to cover the latest research results on non-motor physiological functions of the cerebellum, where recent research is accelerating beyond the research on the motor function of the cerebellum. We will address the physiological mechanisms by which the cerebellum contributes to non-motor mental activities such as emotion, cognition, and perception.

• Timothy F. Osborne (Johns Hopkins All Children’s Hospital, USA)
  

  Transcriptional Drivers of Metabolic Adaptations

• Juro Sakai (The University of Tokyo, Japan)
  

  Cold-signal-sensing histone demethylase regulates brown and beige adipocyte activation by distinct mechanisms to prevent obesity

• Jae Bum Kim (Seoul National University, Korea)
  

  Adipose Tissue Plasticity and Energy Metabolism

• Seung-Hoi Koo (Korea University, Korea)
  

  Role of CRTC2 in metabolic derangement

In this session, we would like to introduce the latest insights on metabolic diseases and research to identify the pathogenesis of physiological signaling and related metabolic diseases.

• Cantas Alev (Kyoto University, Japan)
  

  Reconstituting human axial development and disease in vitro

• Kunyoo Shin (Seoul National University, Korea)
  

  Human Assembloids to Study the Basic Principle of Human Diseases

• Jaecheol Lee (Sungkyunkwan University, Korea)
  

  The modeling strategy of human disease using patient-specific induced pluripotent stem cells

• Jae-Yol Lim (Yonsei University College of Medicine, Korea)
  

  Translational applications of salivary gland stem cell-derived organoids

Disease model systems are essential for understanding human physiology and pathophysiology. However, the value of employing human models for drug development has only recently been fully appreciated. The ability to efficiently identify and eliminate drugs lacking efficacy or causing severe toxicities can significantly enhance the success rate of costly and time-consuming clinical trials. Moreover, human stem cell-based disease modeling platform can provide novel mechanisms and therapeutic targets for drug development. This session will discuss recent advances in stem cell-based disease modeling, their utility as preclinical testing platforms for drug target validation, and their critical role in the future of drug discovery, as well as the advances in the development of cell therapeutics.

• Calogera Simonaro (Mount Sinai School of Medicine, USA)
  

  Diseases Of Glycosaminoglycan Metabolism: Novel Insights & New Therapies

• Beom Hee Lee (Asan Medical Center Children's Hospital, Korea)
  

  Phase II study of safety and efficacy of selumetinib in Korean patients with NF1.

• Seung Hyun Kim (Hanyang University Medical Center, Korea)
  

  Development of precisional and stratified therapeutic strategy for ALS

• Bum-Joon Park (Pusan National University, Korea)
  

  New drug development for NF2 syndrome based on non-canonical TGF-B signaling inhibition

This session will introduce the cases of efficacy and safety evaluation through clinical trials from basic and translational research using new therapeutic targets and treatments for rare genetic diseases.

• Yoshikatsu Kanai (Osaka University, Japan)
  

  Cryo-EM structure of amino acid transporter LAT1 and related amino acid signaling downstream of LAT1

• Shmuel Muallem (NIH, USA)
  

  A Plasma Membrane PtdSer subdomain specified by E-Syt3 is essential for assembly of signaling complexes at MCS that activate the HCO3- transporters CFTR and NBCe1-B

• Liang Ge (Tsinghua University, China)
  

  Cargo translocation on the ERGIC in unconventional secretion

• Min Goo Lee (Yonsei University, Korea)
  

  Unconventional proteins secretion of CFTR, Pendrin, and SARS-CoV-2

Transepithelial transport of ions, small molecules, and proteins across various epithelial cells play an essential role in our bodily function. In this symposium, recent advances in intracellular regulation of membrane transport and protein secretion will be presented and discussed, with a specific focus on their molecular mechanisms and potential applications in the related human diseases.

• Young-Min Hyun (Yonsei University, Korea)
  

  Material X aggravate the innate immune response through strong adherence to and engulfment by neutrophils and macrophages

• Sun Kwang Kim (Kyung Hee University, Korea)
  

  Two-Photon Microscopy Imaging of Synaptic Structures, Neuronal/Glial Calcium and Cerebrospinal Fluid in Living Mice

• Hiroaki Wake (Nagoya University, Japan)
  

  Holographic microscope for multi-cellular measurement and manipulation

• Valentin Nägerl (University of Bordeaux, France)
  

  Getting sharper: super-resolution imaging of dynamic brain microstructures

Recent advances in the microscopy and fluorescent labeling technology have enabled many physiological findings that previously unknown. In this session, the application of cutting-edge microscopy imaging technology in physiology research will be introduced, including a real-time intravital/two-photon imaging of immune cells/neurons/glia and tissues/organs in living animals, a holographic microscope for multicellular imaging and stimulation, and a nanoscale imaging using super-resolution microscopy.

• Sang Don Koh (University of Nevada School of Medicine, USA)
  

  Functional Role of Detrusor Interstitial Cells During Bladder Filling

• Masatoshi Hori (University of Tokyo, Japan)
  

  Functional and morphological abnormalities of Interstitial Cells of Cajal (ICC) in gastrointestinal disorders

• Jae Yeol Jun (Chosun University, Korea)
  

  Ion Channels for the Spontaneous Rhythm and Contractility Regulation in Colonic Interstitial Cells of Cajal

• Young Min Bae (Konkuk University School of Medicine, Korea)
  

  Contribution of the Na+-leak channel NALCN to arterial contractility in health and disease

• Hiroki TOYODA (Osaka University, Japan)
  

  Impairment of autoinhibition in locus coeruleus neurons is involved in the pathogenesis of Alzheimer disease

• Man-Kyo Chung (University of Maryland, USA)
  

  Neurobiology of capsaicin-induced analgesia for trigeminal neuropathic pain

• Dong Kuk Ahn (Kyungpook National University, Korea)
  

  A role of central angiotensin Ⅱ in orofacial pain

• Koichi Iwata (Nihon University, Japan)
  

  Role of non-neuronal cells in persistent orofacial pain

• Seog Bae Oh (Seoul National University, Korea)
  

  Transcriptome profiling of dental sensory system by single-cell RNA sequencing

Trigeminal somatosensory system plays crucial roles in our eating behaviors by regulating masticatory function and masticatory dysfunction is also known to affect cognitive function. Orofacial pain such as trigeminal neuralgia and tooth pain is common disease in the trigeminal somatosensory system. This symposium covers recent advances in our understanding of trigeminal somatosensory system, with focus on the neurobiological mechanisms of orofacial pain and role of trigeminal proprioception in cognitive disorder.

• Jinhee Yang (BIORCHESTRA Co., LTD., Korea)
  

  Development of Brain-targeting MicroRNA-based ASO Formulation against Neurodegenerative Diseases

• Minyeop Nahm (Korea Brain Research Institute, Korea)
  

  Dysregulation of RNA Binding Proteins in ALS

• Ki-wook Oh (Hanyang University Hospital, Korea)
  

  Therapeutic strategies of autologous MSC for ALS patients: current and future perspectives

• Kee Hyung Park (Gachon University Gil Medical Center, Korea)
  

  New Horizons of Alzheimer's Disease Treatment Strategy: Focusing on Newly Approved Amyloid-Based Monoclonal Antibodies

• Young Bin Hong (Dong-A University, Korea)
  

  Targeting TDP-43 aggregation improves the phenotype of amyotrophic lateral sclerosis

This session will explore recent progress and challenges in biomedical research, therapeutics and diagnostics development, and regulatory science related to neurodegenerative disease. A joint engagement amongst all stakeholders is needed in order to strengthen innovative research strategies and to accelerate its translation into clinical practice.

• Maria Grammatikopoulou (University of Thessaly, Greece)
  

  A systematic review of the physiological effects of traditional regional diets targeting the prevention of cardiovascular disease

• Markos Klonizakis (Sheffield Hallam University, United Kingdom)
  

  Effects of Long- and Short-Term Exposure to the Mediterranean Diet on Skin Microvascular Physiology

• Ryoichi Nagatomi (Tohoku University, Japan)
  

  Contribution of traditional Japanese diet on cardiovascular health but not on musculoskeltal health - possible association of adiponectin

• Alexandros Mitropoulos (Sheffield Hallam University, United Kingdom)
  

  Physiological effects of the New Nordic diet on high cardiovascular disease-risk adults

"Among all Non-communicable Diseases (NCD), Cardiovascular disease (CVD) is one of the leading cause of disease burden globally, demonstrating an alarmingly high rate. Moreover, over the past few years, the global epidemiological CVD landscape has changed dramatically, with unhealthy diet becoming an increasingly important modifiable factor for the development of CVD causes.
Nutrition-based lifestyle interventions have been recommended as a primary and secondary prevention strategy for NCDs and for CVD in particular, for all high-risk populations (e.g., those who are obese, physically inactive, smoking, consuming unhealthy diets or excessive amounts of alcohol etc). Traditional regional diets are considered as sustainable dietary patterns, while many have been examined with regard to their health benefits. The aim of the proposed symposiu will be to aggregate all evidence on the physiological effects of a series of regional diets among adults at high risk for cardiovascular disease."

• Francesca Levi-Schaffer (Hebrew University of Jerusalem, Israel)
  

  The Interactions between eosinophils and mast cells (THE Allergic Effector Unit) as the ultimate pro-inflammatory cross-talk?

• Naohiko Anzai (Chiba University Graduate School of Medicine, Japan)
  

  Renal tubular urate transporters and hyperuricemia

• Chang-Hoon Woo (Yeungnam University College of Medicine, Korea)
  

  Role of CHIP ubiquitin ligase in hepatic steatosis

• Sang-Hyun Kim (Kyungpook National University, Korea)
  

  IRF3/IP-10 axis as a new target for atopic dermatitis

In this session, the new pharmacological targets for various diseases will be introduced, including allergic inflammation, renal physiology, and hepatic steatosis.

• Ju-Hee Kang (Inha University, Korea)
  

  Regulation of fat metabolism by exercise-induced metabolic intermediates

• Dae yun Seo (Inje University, Korea)
  

  The role of cereblon in exercise-induced animal and human models

• Kwangseok Hong (Chung-Ang University, Korea)
  

  Can exercise intervention reverse the impairment of endothelial TRPV4 channel function in obesity?

• Seungyong Lee (Incheon National University, Korea)
  

  Novel direction for potential restorative effects of bone metabolism with aerobic and resistance combined exercise in ovariectomized (OVX)-induced osteoporotic rats

• Hyeonwoo Kim (KAIST, Korea)
  

  Decoding Exercise at Molecular Levels and Health

The symposium provides the effects of acute and chronic exercise on cardiovascular system, muscle metabolism, and skeletal system in the cell, animal, and human models, including the cellular and molecular mechanisms.

• Ayal Ben-Zvi (Hebrew University of Jerusalem, Israel)
  

  Special Neuro-glia-vascular interactions in different brain regions uncovered through use of classical and advanced microscopy

• Won Jong Oh (Korea Brain Research Institute (KBRI), Korea)
  

  Distinct function of common guidance cues in the nervous versus vascular system

• Hyungju Park (Korea Brain Research Institute (KBRI), Korea)
  

  Selective reorganization of excitatory synapses by astrocytic phagocytosis in the adult striatum

• Hyosang Lee (DGIST, Korea)
  

  Astrocytes in the lateral septum modulate stress responses

Growing evidence indicates that non-neuronal cells in the brain play a critical role in modulating neural circuit functions and behavior. This symposium of four talks will discuss how neurons, astrocytes, and vascular cells interact to elicit physiological and behavioral outcomes.

• Kiwon Ban (City University of Hong Kong, Hong Kong, Hong Kong)
  

  Development of novel strategies for cell-based cardiac repair/regeneration

• Hyuk-Jin Cha (Seoul National University, Korea)
  

  Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction

• Tae-Hyung Kim (Chung-Ang University, Korea)
  

  Electrochemical detection of cellular metabolism and its application for stem cell-based drug screening

• Jaecheol Lee (Sungkyunkwan University, Korea)
  

  Disease modeling using patient-specific induced pluripotent stem cells

Stem cell therapy stands as a pivotal realm of research, spearheading a paradigm shift in forthcoming medical technology through the realization of regenerative medicine. The creation of personalized, high-functional stem cell treatments for patients not only promises a lucrative industry with anticipated growth but also spurs active strategic research for global market entry. As stem cell therapeutics transition into commercially viable technology, the exploration of enhanced treatment effectiveness and widened applications is burgeoning. This symposium extends a warm invitation to distinguished researchers in stem cell therapy development, safety assurance technology, tissue/material engineering, disease modeling, and exosome studies. Together, we will uncover the latest technological trajectories in the domain of stem cell and regenerative medicine, while deliberating on the imperative for interdisciplinary convergence research across these fields.

• Myeongjin Song (NEXEL Co., Ltd., Korea)
  

  Drug Evaluation using Human Pluripotent Stem Cell-derived Cardiac Cell Model.

• Sonja Stoelzle-Fei (Nanion Technologies GmbH, Germany)
  

  Chronic and acute drug-induced cardiotoxicity assessment using in vitro human iPSC-cardiomyocytes

• Nick Geisse (CuriBio Inc., USA)
  

  High-throughput Assessment of Cardiac Safety via Calcium and Voltage Imaging of 3D Engineered Heart Tissues and 2D Cell Cultures Using a Novel Instrumentation Platform

The implementation of the ICH S7B and E14 in 2005 has been successfully prevented the introduction of
potential arrhythmic drugs to the market. However, it has focused only on hERG block and in vivo QT
prolongation as essential determinants of arrhythmia risk. The Comprehensive In vitro Proarrhythmia Assay (CiPA) initiative was begun in 2013, thereafter, an international multi-disciplinary team of regulatory, industry and academic scientists has been working together to develop in vitro human relevant platform as a proarrhythmic model to explore the activities of ion channels other than the rapidly activating potassium channel. As a result, the new ICH E14/S7B Q&A was recently adopted, and it includes the best practice considerations for in vitro studies to address the different aspects of cardiomyocyte repolarization against the investigational drugs. This symposium will highlight new and relevant in vitro platforms for evaluating cardiac safety of drugs beyond the hERG assay and in vivo QT prolongation.

• Can Ince (Erasmus Medical Center, Netherlands)
  

• Vidya Sudarshan (Nanyang Technological University, Singapore)
  

  Interpretable - CEnter-Net: Interpretable Hybrid Model for Automated Multi-class Classification of ECG Signal Based on the Type of Arrhythmia Rhythms

• Nari Kim (Inje University College of Medicine, Korea)
  

  Empowering Predictive Precision with Computational Fluid Dynamics in Atherosclerosis Prognosis

• Lan Feng (Chinese Academy of Medical Sciences and Peking Union Medical College, China)
  

  Genome editing based therapy for cardiovascular diseases

Better CVD diagnosis and treatment

• Pilhan Kim (KAIST, Korea)
  

  Real-time Intravital Microscopy with Suction-assisted Imaging Windows for Thoracic Organ Imaging

• Sumin Lee (Tomocube, Korea)
  

  Label-free 3D Live Cell Imaging and Quantification using Holotomography